I completed my PhD in 2017 at the University of Nottingham in Cancer biology where I utilised the TCGA resources to investigate potential therapeutic microRNA targets to be tested on cell lines in the lab. This was followed by a postdoctoral position at the University of Birmingham which focused upon characterising the non-coding parts (lncRNA, eRNA, etc) of the genome utilising zebrafish as a model organism. This position facilitated my understanding in a wide range of sequencing technologies and analyses; including CAGE, ChIP, ATAC and RNA-seq. Since starting my position at UEA, I have continued to develop my skills in bioinformatics and analysing samples for DNA variants. Facilitating this, I have developed skills in pipelining programming languages including Nextflow and Snakemake, with integration into containerisation technology such as Singularity.
| Publications |
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| de Brot, S., Ntekim, A., Cardenas, R., James, V., Allegrucci, C., Heery, D.M., Bates, D.O., Ødum, N., Persson, J.L. and Mongan, N.P., 2015. Regulation of vascular endothelial growth factor in prostate cancer. Endocrine-related cancer, 22(3), pp.R107-R123. |
| Nepal, C., Hadzhiev, Y., Balwierz, P., Tarifeño-Saldivia, E., Cardenas, R., Wragg, J.W., Suzuki, A.M., Carninci, P., Peers, B., Lenhard, B. and Andersen, J.B., 2020. Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing. Nature communications, 11(1), pp.1-16. |
| Ramilowski, J.A., Yip, C.W., Agrawal, S., Chang, J.C., Ciani, Y., Kulakovskiy, I.V., Mendez, M., Ooi, J.L.C., Ouyang, J.F., … Cardenas, R.P, … Parkinson, N. and Petri, A., 2020. Functional annotation of human long noncoding RNAs via molecular phenotyping. Genome Research, 30(7), pp.1060-1072. |
| Shah, M., Cardenas, R., Wang, B., Persson, J., Mongan, N.P., Grabowska, A. and Allegrucci, C., 2017. HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells. Molecular cancer, 16(1), p.38. |
| Mok, G.F., Cardenas, R., Anderton, H., Campbell, K.H. and Sweetman, D., 2014. Interactions between FGF18 and retinoic acid regulate differentiation of chick embryo limb myoblasts. Developmental biology, 396(2), pp.214-223. |
Interests
- Epigenetics
- Bioinformatics
- Cancer
- Statistics and modelling
- Containerisation technologies